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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].
Show detailsBibliographic details: Mosges R, Nematian-Samani M, Eichel A. Treatment of acute otitis externa with ciprofloxacin otic 0.2% antibiotic ear solution. Therapeutics and Clinical Risk Management 2011; 7: 325-336. [PMC free article: PMC3150478] [PubMed: 21845055]
Abstract
BACKGROUND/OBJECTIVE: An inflammation of the cutis and subcutis of the external auditory canal is a primary symptom in cases of acute otitis externa. It is usually treated locally, since this type of therapy ensures a high concentration of the drug and interacts at the site of inflammation with no systemic effects. This systematic review compares the efficacy of treatment using a ciprofloxacin 0.2% solution with other therapeutic options.
METHODS: After compiling a catalog of search terms, medical databases were searched systematically for randomized, controlled studies. This search initially yielded a total of 38 studies which were then evaluated by three independent reviewers. The number of studies was subsequently reduced to 14: six studies using a ciprofloxacin 0.2% solution, and eight studies using both 0.2% and 0.3% solutions.
RESULTS: The studies included in the review demonstrate the statistical equivalence between the ciprofloxacin solution (0.2%) and the reference products PNH (a combination of polymyxin B, neomycin sulfate and hydrocortisone), auriculum powder, and a ciprofloxacin foam with respect to the cure rate. The research groups consistently observed high in vitro activity of ciprofloxacin against Pseudomonas aeruginosa.
CONCLUSION: This systematic review confirms the hypothesis of ciprofloxacin's noninferiority in the treatment of otitis externa, in terms of the cure rate and microbiological eradication.
- Comparison of efficacy and safety of ciprofloxacin otic solution 0.2% versus polymyxin B-neomycin-hydrocortisone in the treatment of acute diffuse otitis externa*.[Curr Med Res Opin. 2008]Comparison of efficacy and safety of ciprofloxacin otic solution 0.2% versus polymyxin B-neomycin-hydrocortisone in the treatment of acute diffuse otitis externa*.Drehobl M, Guerrero JL, Lacarte PR, Goldstein G, Mata FS, Luber S. Curr Med Res Opin. 2008 Dec; 24(12):3531-42.
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- Review Interventions for acute otitis externa.[Cochrane Database Syst Rev. 2010]Review Interventions for acute otitis externa.Kaushik V, Malik T, Saeed SR. Cochrane Database Syst Rev. 2010 Jan 20; (1):CD004740. Epub 2010 Jan 20.
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- Treatment of acute otitis externa with ciprofloxacin otic 0.2% antibiotic ear so...Treatment of acute otitis externa with ciprofloxacin otic 0.2% antibiotic ear solution - Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews
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