Table 5.4GRADE summary of findings for mother-to-child transmission (MTCT) of HIV

Number of studiesNumber of womenEffectQuality
Planned CSVaginal birthRelative

(95% CI)
Absolute

(95% CI)
Mother-to-child transmission (MTCT) in women with viral load < 50 copies/ml on highly active anti-retroviral therapy (HAART)
1 study

(Boer et al., 2010)
1/238

(0.4%)
1/321

(0.3 %)
OR 1.35

(0.08 to 21.6)b
1 more per 1000

(from 1 fewer to 60 more)
Very low
1 study

(Townsend et al., 2008)
2/1135

(0.2%)
1/417a

(0.2%)
OR 0.73

(0.06 to 8.12)b
Not calculable (NC)Very low
MTCT in women with viral load < 50 copies/ml; 14/23 on HAART
1 study

(Islam et al., 2010)
Not reported (NR)0/23

(0%)a
NCNCVery low
MTCT in women with viral load ≥ 50 and < 1000 copies/ml on HAART
1 study

(Townsend et al., 2008)
4/417

(0.95%)
2/81a

(2.5%)
OR 0.39

(0.07 to 2.17) b
15 fewer per 1000

(from 23 fewer to 27 more)
Very low
MTCT in women with viral load < 400 copies/ml with and without HAART
1 study

(Boer et al., 2010)
4/571

(0.7%)
11/242

(4.5%)
OR 0.14

(0.04 to 0.47)b
38 fewer per 1000

(from 24 fewer to 44 fewer)
Very low
MTCT in women with viral load < 400 copies/ml on antenatal antiretroviral therapy (ART) (term birth)
1 study

(Warszawski et al., 2008)
7/1296

(0.5%)
7/1083

(0.6%)
OR 0.83

(0.29 to 2.38)b
1 fewer per 1000

(from 5 fewer to 9 more)
Very low
MTCT women with viral load < 1000 copies/ml on HAART
1 study

(Boer et al., 2010)
3/424

(0.7%)
0/155

(0%)
NCNCVery low
MTCT in women with viral load ≥ 1000 copies/ml on HAART
1 study

(Boer et al., 2010)
11/822

(1.3%)
2/310

(0.6%)
OR 2.08

(0.46 to 9.47) b
7 more per 1000

(from 3 fewer to 50 more)
Very low
MTCT in women with viral load ≥ 10,000 copies/ml on antenatal ART including HAART (term birth)
1 study

(Warszawski et al., 2008)
10/203 (4.9%)5/72 (6.9%)OR 0.69

(0.22 to 2.10) b
20 fewer per 1000

(from 53 fewer to 60 more)
Very low
a

planned vaginal birth

b

calculated by NCC technical team

CI confidence interval; NC not calculable; OR odds ratio

From: 5, Planned caesarean section

Cover of Caesarean Section
Caesarean Section.
NICE Clinical Guidelines, No. 132.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2011 Nov.
Copyright © 2011, National Collaborating Centre for Women's and Children's Health.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK [www.cla.co.uk]. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.