C.3.1Review question 1

How useful are simple clinical measures for targeting people for risk assessment of fragility fracture?

PopulationAdult men or women (over 18 years), including those without known osteoporosis or previous fragility fracture.
Prognostic factorBMI, oral glucocorticoid use, family history of fracture, previous fracture, smoking, alcohol, history of falls.
OutcomesRisk of fractures including:
  • vertebral
  • hip
  • any fragility fracture.
Inclusion/exclusion criteriaWhere meta-analyses based on individual patient data are available, these are reviewed and other types of evidence such as meta-analysis, systematic reviews, cohort studies, case-control studies and cross-sectional studies are not included. Hierarchy of evidence (only go down a level if there is a lack of literature): Minimum number of fractures reported in study (event rate): 100.
Study typesIPD meta-analyses (when available); prospective cohort

From: Appendix C, How this guideline was developed

Cover of Osteoporosis: Fragility Fracture Risk
Osteoporosis: Fragility Fracture Risk: Osteoporosis: Assessing the Risk of Fragility Fracture.
NICE Clinical Guidelines, No. 146.
National Clinical Guideline Centre (UK).
Copyright © 2012, National Clinical Guideline Centre.

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