Table 1062 % Chlorhexidine gluconate (CHG) in aqueous vs. 10% Povidone Iodine (PVP-I) in aqueous – Clinical study characteristics

OutcomeNumber of studiesDesignLimitationsInconsistencyIndirectnessImprecision
VAD related bacteraemia155,2642RCTSerious limitations (a)No serious inconsistencyNo serious indirectnessSerious imprecision (b)
VAD related septicaemia2641RCTSerious limitations (a)No serious inconsistencyNo serious indirectnessSerious imprecision (b)
Catheter tip colonisation155,2642RCTSerious limitations (a)No serious inconsistencyNo serious indirectnessSerious imprecision (b)
VAD related local infection0RCT
VAD related phlebitis0RCT
Infection related mortality0RCT
VAD line removal0RCT
a

Block randomisation followed by physically different interventions (not blinded) – unclear whether there were adequate allocation concealment methods,264 randomisation (done per catheter instead of patients) sequence generation and allocation concealment unclear.155

b

Confidence intervals wide- crossed threshold(s) of clinically important harms and benefits.

From: 12, Vascular access devices

Cover of Infection: Prevention and Control of Healthcare-Associated Infections in Primary and Community Care
Infection: Prevention and Control of Healthcare-Associated Infections in Primary and Community Care: Partial Update of NICE Clinical Guideline 2.
NICE Clinical Guidelines, No. 139.
National Clinical Guideline Centre (UK).
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