Table 88Transparent semi permeable membrane with iodophor antiseptic vs. gauze and tape – Clinical study characteristics; peripherally inserted VADs

OutcomeNumber of studiesDesignLimitationsInconsistencyIndirectnessImprecision
Phlebitis 1541RCTSerious limitations(a)No serious inconsistencySerious indirectness(b)Serious imprecision(c)
Catheter tip colonisation0RCT
Frequency of dressing change0RCT

Randomised catheter sites rather than patients, therefore patients were included in the study more than once.


The studies are all hospital based rather than community settings.


The relatively few events and few patients give wide confidence intervals around the estimate of effect. This makes it difficult to know the true effect size for this outcome.

From: 12, Vascular access devices

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Infection: Prevention and Control of Healthcare-Associated Infections in Primary and Community Care: Partial Update of NICE Clinical Guideline 2.
NICE Clinical Guidelines, No. 139.
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