Table 88Transparent semi permeable membrane with iodophor antiseptic vs. gauze and tape – Clinical study characteristics; peripherally inserted VADs

OutcomeNumber of studiesDesignLimitationsInconsistencyIndirectnessImprecision
Phlebitis 1541RCTSerious limitations(a)No serious inconsistencySerious indirectness(b)Serious imprecision(c)
Catheter tip colonisation0RCT
Frequency of dressing change0RCT
Mortality0RCT
Bacteraemia0RCT
a

Randomised catheter sites rather than patients, therefore patients were included in the study more than once.

b

The studies are all hospital based rather than community settings.

c

The relatively few events and few patients give wide confidence intervals around the estimate of effect. This makes it difficult to know the true effect size for this outcome.

From: 12, Vascular access devices

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Infection: Prevention and Control of Healthcare-Associated Infections in Primary and Community Care: Partial Update of NICE Clinical Guideline 2.
NICE Clinical Guidelines, No. 139.
National Clinical Guideline Centre (UK).
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