Table 6Procalcitonin-guided antibiotic discontinuation in the critically ill/ventilator-associated pneumonia patients––morbidity

OutcomeAuthor, YearNPCTΨControlΨDifference, PCT-CTRL (95% CI)p-Value
LOS (days)Nobre, 200832791723.5-2.5 (-6.5, 1.5)0.85
Stolz, 20093510126 (7-21)26 (16.8-22.3)00.15
Bouadma, 20103962126.126.4-0.3 (-3.2, 2.7)0.87
ICU LOS (days)Hochreiter, 20093411015.517.7-2.20.046
Nobre, 2008327947-4.6 (-8.2, -1.0)0.02
Schroeder, 2009332716.416.7-0.3,(-5.6, 5.0)NSS
Bouadma, 20103962115.914.41.5 (-0.9, 3.1)0.23
ICU-free days alive, 1-28Stolz, 20093510110 (0-18)8.5 (0-18)1.50.53
SOFA day 28Bouadma, 2010396211.50.90.6 (0.0, 1.1)0.037
SOFA score maxSchroeder, 200933277.38.3-8.1 (-4.1, 1.7)NSS
SAPS II scoreHochreiter, 20093411040.140.5-0.4 (-6.4, 5.6)> 0.05
Days without MVStolz, 20093510121 (2-24)19 (8.5-22.5)2.00.46
Bouadma, 20103962116.216.9-0.7 (-2.4, 1.1)0.47

CI = confidence interval; CTRL = control; ICU = intensive care unit; LOS = length of stay; MV = mechanical ventilation; NSS = not statistically significant; PCT = procalcitonin; SAPS = Simplified Acute Physiology Score; SOFA = Sepsis-Related Organ Failure Assessment

Ψ

All values are mean unless specified.

Median (interquartile range).

From: Results

Cover of Procalcitonin-Guided Antibiotic Therapy
Procalcitonin-Guided Antibiotic Therapy [Internet].
Comparative Effectiveness Reviews, No. 78.
Soni NJ, Samson DJ, Galaydick JL, et al.

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