Table 6Example of GRADE evidence profile

Quality assessmentSummary of findings
No. of service usersEffectQuality
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOtherInterventionControlRelative
(95% CI)
Absolute
Outcome 1
6Randomised trialNo serious limitationsNo serious inconsistencyNo serious indirectnessVery serious1,2None8/1917/150RR 0.94
(0.39 to 2.23)
0 fewer per 100
(from 3 fewer to 6 more)
⊕⊕○○
LOW
Outcome 2
6Randomised trialNo serious limitationsNo serious inconsistencyNo serious indirectnessNo serious imprecisionNone120/600220/450RR 0.39
(0.23 to 0.65)
30 fewer per 100
(from 17 fewer to 38 fewer)
⊕⊕⊕⊕
HIGH
Outcome 3
3Randomised trialNo serious limitationsNo serious inconsistency3No serious indirectnessVery serious1,2None8381MD −3.51
(−11.51 to 4.49)
⊕○○○
VERY LOW
Outcome 4
3Randomised trialNo serious limitationsNo serious inconsistencyNo serious indirectnessSerious1None8893SMD −0.26
(−0.50 to −0.03)
⊕⊕⊕○
MODERATE
Outcome 5
4Randomised trialNo serious limitationsNo serious inconsistencyNo serious indirectnessVery serious1,2None109114SMD −0.13
(−0.6 to 0.34)
⊕⊕○○
LOW
1

Optimal information size (OIS) (for dichotomous outcomes, OIS = 300 events; for continuous outcomes, OIS = 400 participants) not met.

2

The CI includes both (1) no effect and (2) appreciable benefit or appreciable harm.

3

Considerable heterogeneity

From: 3, METHOD USED TO DEVELOP THIS GUIDELINE

Cover of Psychosis with Coexisting Substance Misuse
Psychosis with Coexisting Substance Misuse: Assessment and Management in Adults and Young People.
NICE Clinical Guidelines, No. 120.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2011.
Copyright © 2011, The British Psychological Society & The Royal College of Psychiatrists.

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