Table 2American College of Rheumatology - European League Against Rheumatism classification criteria for rheumatoid arthritisa (revised 2010)

A. Joint involvementScore
 1 large joint0
 2–10 large joints1
 1–3 small joints2
 4–10 small joints3
 >10 joints5
B. Serology
 Negative RF and negative ACPA0
 Low-positive RF or low-positive ACPA2
 High-positive RF or high-positive ACPA3
C. Acute-phase reactants
 Normal CRP and normal ESR0
 Abnormal CRP or abnormal ESR1
D. Duration of symptoms
 <6 weeks0
 ≥6 weeks1

Abbreviations: ACPA, anti citrullinated protein antibody; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; RF, rheumatoid factor.


A score of ≥6/10 is needed for classification of a patient as having definite rheumatoid arthritis.3

Target population for this test:

  1. Patients who have at least 1 joint with definite clinical synovitis (swelling)
  2. Patients with the synovitis not better explained by another disease.


Cover of Drug Class Review: Targeted Immune Modulators
Drug Class Review: Targeted Immune Modulators: Final Update 3 Report [Internet].
Thaler KJ, Gartlehner G, Kien C, et al.
Portland (OR): Oregon Health & Science University; 2012 Mar.
Copyright © 2012, Oregon Health & Science University, Portland, Oregon.

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