Table 3Overview of the patient-relevant outcomes in the studies on venlafaxine

DepressionIndividual and accompanying symptomsAdverse eventsSexual dysfunctionHealth-related quality of lifeSocial functioning level
Venlafaxine versus placebo
Acute trials
anxiety, energy
 Long-term trials (relapse/ recurrence prevention)• / •− / •
• / •− / •− / •
Venlafaxine versus SSRIa
Acute trials
anxiety, pain, cognition, sleep
Venlafaxine versus TCAb
Acute trials
anxiety, cognition
Venlafaxine versus agomelatine
Acute trials
Venlafaxine versus bupropion
Acute trials
anxiety, energy
Venlafaxine versus mirtazapine
Acute trials
Venlafaxine versus moclobemide
Acute trials(•)
Venlafaxine versus trazodone
Acute trials

Data on at least one of the following drugs: citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline


Data on at least one of the following drugs: amitriptyline, clomipramine, dosulepin, imipramine, maprotiline, nortriptyline

• : Data reported

(•): Data collected but not reported

SSRI: selective serotonin reuptake inhibitors; TCA: tri- and tetracyclic antidepressants

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