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First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet]

First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet]

Comparative Effectiveness Reviews - Agency for Healthcare Research and Quality (US)

Version: August 2012

Introduction

Antipsychotic medications are used to treat and manage symptoms for several psychiatric disorders and are commonly categorized into two classes. First-generation antipsychotics (FGAs), also known as “typical antipsychotics,” were developed in the 1950s. Second-generation antipsychotics (SGAs), also known as “atypical antipsychotics,” emerged in the 1980s. To date, FGAs have been classified according to their chemical structure, which includes serotonin-dopamine antagonists and multi-acting receptor-targeted antipsychotics, whereas SGAs have been categorized according to their pharmacological properties as dopamine partial agonists. There is ongoing research testing these proposed mechanisms of action within each class with respect to the neurobiology of different psychiatric disorders.,

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