Table CSummary of evidence for functional outcomes, health care system utilization, and other outcomes (KQ2)

OutcomeComparisonSummary (Number of Studies)
Schizophrenia and Schizophrenia-Related Psychoses
Functional outcomesFluphenazine vs. quetiapineNo significant difference for sexual dysfunction or improvement on treatment (1 RCT).
Fluphenazine vs. risperidoneNo significant difference for sexual dysfunction or improvement on treatment (1 RCT).
Haloperidol vs. olanzapineNo significant difference for positive urine toxicology (1 RCT) or sexual dysfunction (1 RCT).
Haloperidol vs. quetiapineNo significant difference for sexual dysfunction (1 RCT).
Haloperidol vs. risperidoneNo significant difference for economic independence (1 RCT) or attitude regarding drugs (1 RCT).
Haloperidol vs. ziprasidoneNo difference for sexual dysfunction (1 RCT).
Perphenazine vs. quetiapineNo significant difference in patients with paid employment (1 RCT).
Perphenazine vs. risperidoneNo significant difference in patients with paid employment (1 RCT).
Perphenazine vs. ziprasidoneNo significant difference in patients with paid employment (1 RCT).
Health care system useChlorpromazine vs. clozapineNo significant difference in rates of hospitalization or rehospitalization (1 RCT).
Haloperidol vs. clozapineNo significant difference in mean hospital bed days (1 RCT).
Haloperidol vs. olanzapineNo significant difference in mean hospital bed days or rates of hospitalization or rehospitalization (1 RCT).
Haloperidol vs. quetiapineNo significant difference in rates of hospitalization or rehospitalization (1 RCT).
Haloperidol vs. risperidoneNo significant difference in rates of hospitalization or rehospitalization (3 RCTs).
Haloperidol vs. ziprasidoneNo significant difference in rates of hospitalization or rehospitalization (2 RCTs).
Perphenazine vs. olanzapineNo significant difference in rates of hospitalization or rehospitalization (1 RCT).
Perphenazine vs. quetiapineNo significant difference in rates of hospitalization or rehospitalization (1 RCT).
Perphenazine vs. risperidoneNo significant difference in rates of hospitalization or rehospitalization (1 RCT).
Perphenazine vs. ziprasidoneNo significant difference in rates of hospitalization or rehospitalization (1 RCT).
Bipolar Disorder
Functional outcomesHaloperidol vs. olanzapineSignificant difference favoring olanzapine for number of active workers (i.e., work for pay) (1 RCT). No difference in impairment in household or work activities (1 RCT).

KQ = Key Question; RCT = randomized controlled trial

From: Executive Summary

Cover of First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 63.
Abou-Setta AM, Mousavi SS, Spooner C, et al.

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