Table 67Patient flow through trials–haloperidol versus quetiapine

Intervention #1Intervention #2Intervention #3Intervention #4Intervention #5Intervention #6
Arvanitis et al. 199746ClassificationFGASGASGASGASGASGA
MedicationHaloperidolQuetiapineQuetiapineQuetiapineQuetiapineQuetiapine
Dosage12mg/d75mg/d150mg/d300mg/d600mg/d750mg/d
No screened:402
No randomized:525348525154
No completed:181721242726
No analyzed (E):505248515153
No analyzed (S):525348525154
Atmaca et al. 200247ClassificationFGASGA
MedicationHaloperidolQuetiapine
Dosage10mg/d600mg/d
No screened:NR
No randomized:1718
No completed:1718
No analyzed (E):1718
No analyzed (S):1718
Copolov et al. 200068ClassificationFGASGA
MedicationHaloperidolQuetiapine
Dosage1–16mg/d50–800mg/d
No screened:NR
No randomized:227221
No completed:147152
No analyzed (E):218213
No analyzed (S):227221
Davidson et al. 200975ClassificationFGASGASGASGA
MedicationHaloperidolOlanzapineQuetiapineZiprasidone
Dosage1–4mg/d5–20mg/d200–750mg/d40–160mg/d
No screened:NR
No randomized:10310410582
No completed:52607445
No analyzed (E):52607445
No analyzed (S):52607445
Emsley et al. 200079ClassificationFGASGA
MedicationHaloperidolQuetiapine
Dosage5–20mg/d600mg/d
No screened:365
No randomized:145143
No completed:135127
No analyzed (E):141140
No analyzed (S):141140
Emsley et al. 200580ClassificationFGASGA
MedicationHaloperidolQuetiapine
Dosage5–20mg100–800mg
No screened:47
No randomized:2322
No completed:1512
No analyzed (E):2322
No analyzed (S):2322
Glick et al. 200565ClassificationFGASGA
MedicationHaloperidolQuetiapine
Dosage200mg/wk500mg/d
No screened:NR
No randomized:1421
No completed:57
No analyzed (E):715
No analyzed (S):916
Kahn et al. 200891ClassificationFGASGASGASGA
MedicationHaloperidolOlanzapineQuetiapineZiprasidone
Dosage1–4mg/d5–20mg/d200–750mg/d40–16mg/d
No screened:1047
No randomized:10310510482
No completed:68827053
No analyzed (E):10310510482
No analyzed (S):10310510482
McCue et al. 200673ClassificationFGASGASGASGASGASGA
MedicationHaloperidolAripiprazoleOlanzapineQuetiapineRisperidoneZiprasidone
Dosage4–30mg10–45mg5–40mg50–1200mg2–9mg40–240mg
No screened:584
No randomized:616362586559
No completed:534950505545
No analyzed (E):575350525750
No analyzed (S):575350525750
Purdon et al. 2001123ClassificationFGASGA
MedicationHaloperidolQuetiapine
Dosage10–20mg/d300–600mg/d
No screened:NR
No randomized:1213
No completed:39
No analyzed (E):1213
No analyzed (S):1213
Velligan et al. 2002143ClassificationFGASGASGA
MedicationHaloperidolQuetiapineQuetiapine
Dosage12mg/d300mg/d600mg/d
No screened:301
No randomized:NRNRNR
No completed:151726
No analyzed (E):151726
No analyzed (S):151726

d = day; E = efficacy; FGA = first-generation antipsychotic; mg = milligram; No = number; NR = not reported; S = safety; SGA = second-generation antipsychotic

From: Appendix I, Patient Flow Through Trials

Cover of First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 63.
Abou-Setta AM, Mousavi SS, Spooner C, et al.

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