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Greenhalgh J, Bagust A, Boland A, et al. Clopidogrel and Modified-Release Dipyridamole for the Prevention of Occlusive Vascular Events (Review of Technology Appraisal No. 90): A Systematic Review and Economic Analysis. Southampton (UK): NIHR Journals Library; 2011 Sep. (Health Technology Assessment, No. 15.31.)

Appendix 4Additional publications associated with each of the main trials

CAPRIE26
Ringleb PA, Bhatt DL, Hirsch AT, Topol EJ, Hacke W. Clopidogrel versus aspirin in patients at risk of ischemic events I. Benefit of clopidogrel over aspirin is amplified in patients with a history of ischemic events. Stroke 2004;35:528–32.
Bhatt DL, Marso SP, Hirsch AT, Ringleb PA, Hacke W, Topol EJ. Amplified benefit of clopidogrel versus aspirin in patients with diabetes mellitus. Am J Cardiol 2002;90:625–8.
Cannon CP, Investigators C. Effectiveness of clopidogrel versus aspirin in preventing acute myocardial infarction with patients with symptomatic atherothrombosis (CAPRIE trial). Am J Cardiol 2002;90:760–2.
Bhatt DL, Chew DP, Hirsch AT, Ringleb PA, Hacke W, Topol EJ. Superiority of clopidogrel versus aspirin in patients with prior cardiac surgery. Circulation 2001;103:363–8.
Bhatt DL, Foody J, Hirsch AT, Ringleb P, Hacke W, Topol EJ. Complementary, additive benefit of clopidogrel and lipid-lowering therapy in patients with atherosclerosis. J Am Coll Cardiol 2000;35(Suppl. A):326.
Bhatt DL, Hirsch AT, Ringleb P, Hacke W, Topol EJ. Reduction in the need for hospitalisation for recurrent ischemic events and bleeding with clopidogrel instead of aspirin. CAPRIE investigators. Am Heart J 2000;140:67–73.
Hacke W, Hirsch AT, Topol EJ. The benefit of clopidogrel over aspirin is amplified in high–risk subgroups with a prior history of ischaemic events. Eur Heart J 1999;20(Suppl.).
Harker LA, Boissel JP, Pilgrim AJ, Gent M. Comparative safety and tolerability of clopidogrel and aspirin. Results from CAPRIE. Drug Saf 1999;21:325–35.
Hacke W. On Behalf of The CAPRIE I. Consistency of the benefit of clopidogrel over aspirin in patients with lacunar and non-lacunar stroke. Cerebrovasc Dis 1998;8:51.
Easton JD. Benefit of clopidogrel in patients with evidence of cerebrovascular disease. Neurology 1998;51:S1–2.
Morais J. Use of concomitant medications in the CAPRIE trial: clopidogrel is unlikely to be associated with clinically significant drug interactions. Eur Heart J 1998;19:182.
Coccheri S. Distribution of symptomatic atherothrombosis and influence of atherosclerotic disease on risk of secondary ischaemic events: Results from CAPRIE. Eur Heart J 1998;19:227.
Blecic S. Atherothrombotic events often indicate disseminated atherosclerosis: data from CAPRIE. Cerebrovasc Dis 1998;8:34.
Hankey G. The risk of vascular ischaemic events in patients with various clinical manifestations of atherothrombosis: data from CAPRIE. Cerebrovasc Dis 1998;8:30.
Rupprecht HJ. Consistency of the benefit of clopidogrel across a range of vascular-related endpoints: results from CAPRIE. Eur Heart J 1998;19(Suppl.):484.
Gent M. Benefit of clopidogrel in patients with coronary disease. Circ Res 1997;96:2608.
ESPS–230
Ariesen MJ, Algra A, Kappelle LJ. Antiplatelet drugs in the secondary prevention after stroke: Differential efficacy in large versus small vessel disease? A subgroup analysis from ESPS–2. Stroke 2006;37:134–8.
Diener HC, Darius H, Bertrand-Hardy JM, Humphreys M. European Stroke Prevention S. Cardiac safety in the European Stroke Prevention Study 2 (ESPS2). Int J Clin Pract 2001;55:162–3.
Sivenius J, Cunha L, Diener HC, Forbes C, Laakso M, Lowenthal A. Second European Stroke Prevention Study: antiplatelet therapy is effective regardless of age. ESPS2 Working Group. Acta Neurol Scand 1999;99:54–60.
Sivenius J, Cunha L, Diener HC, Forbes C, Laakso M, Lowenthal A. Antiplatelet treatment does not reduce the severity of subsequent stroke. European Stroke Prevention Study 2 Working Group. Neurology 1999;53:825–9.
ESPRIT56
Algra A. Medium intensity oral anticoagulants versus aspirin after cerebral ischaemia of arterial origin (ESPRIT): a randomised controlled trial. Lancet Neurology 2007;6:115–24.
Halkes PHA. [Acetylsalicylic acid and dipyridamole offer better secondary protection than acetylsalicylic acid only following transient ischaemic attack or cerebral infarction of arterial origin; the ‘European/Australasian stroke prevention in reversible ischaemia trial’ (ESPRIT)]. Ned Tijdschr Geneeskd 2006;150:1832–8.
PRoFESS
Diener HC. The PRoFESS trial: Future impact on secondary stroke prevention. Expert Rev Neurother 2007;7:1085–91.
Diener HC, Sacco R, Yusuf S. Rationale, design and baseline data of a randomized, double-blind, controlled trial comparing two antithrombotic regimens (a fixed-dose combination of extended-release dipyridamole plus ASA with clopidogrel) and telmisartan versus placebo in patients with strokes: The Prevention Regimen for Effectively Avoiding Second Strokes trial (PRoFESS). Cerebrovasc Dis 2007;23:368–80.
Diener HC, Sacco RL, Yusuf S, Cotton D, Ounpuu S, Lawton WA, et al. Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurring stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study. Lancet Neurol 2008;7:875–84.
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Cover of Clopidogrel and Modified-Release Dipyridamole for the Prevention of Occlusive Vascular Events (Review of Technology Appraisal No. 90): A Systematic Review and Economic Analysis
Clopidogrel and Modified-Release Dipyridamole for the Prevention of Occlusive Vascular Events (Review of Technology Appraisal No. 90): A Systematic Review and Economic Analysis.
Health Technology Assessment, No. 15.31.
Greenhalgh J, Bagust A, Boland A, et al.
Southampton (UK): NIHR Journals Library; 2011 Sep.

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