TABLE 40Adverse events in included head-to-head studies: donepezil vs rivastigmine

AEDonepezilRivastigmineDonepezil vs rivastigmine
Bullock et al. (2005)148Cumbo (2005)99Nordberg et al. (2009)147Bullock et al. (2005)148Cumbo (2005)99Nordberg et al. (2009)147Bullock et al. (2005)148Cumbo (2005)99Nordberg et al. (2009)147
Nn (%)Nn (%)Nn (%)Nn (%)Nn (%)Nn (%)p-valuea
Any AE453349 (77.0)404318 (78.7)0.613
Any serious AE499162 (32.5)495157 (31.7)0.854
Abdominal pain202 (10.0)220 (0.0)0.427
Aggression45325 (5.5)40419 (4.7)0.700
Agitation45347 (10.4)40434 (8.4)0.389
Anorexia45314 (3.1)310 (0.0)40426 (6.4)371 (2.7)0.0310.929
Depression45316 (3.5)40421 (5.2)0.303
Diarrhoea45330 (6.6)200 (0.0)40426 (6.4)222 (9.1)0.9780.512
Dizziness201 (5.0)223 (13.6)0.67
Fall45344 (9.7)40433 (8.2)0.503
Headache45312 (2.6)312 (6.5)202 (10.0)40413 (3.2)371 (2.7)223 (13.6)0.7710.8750.91
Hypertension45318 (4.0)40421 (5.2)0.487
Influenza200 (0.0)221 (4.5)0.962
Injury
Insomnia202 (10.0)221 (4.5)0.932
Muscle spasms203 (15.0)220 (0.0)0.199
Nausea45324 (5.3)312 (6.5)202 (10.0)40452 (12.9)373 (8.1)2210 (45.5)< 0.0010.8370.028
Upper respiratory tract infection201 (5.0)222 (9.1)0.932
Urinary tract infection45326 (5.7)40418 (4.5)0.487
Vomiting45320 (4.4)310 (0.0)200 (0.0)40462 (15.3)371 (2.7)224 (18.2)< 0.0010.9290.139
Weight decrease45343 (9.5)310 (0.0)40436 (8.9)370 (0.0)0.861
Weight loss201 (5.0)222 (9.1)0.932
a

Chi-squared test (Yates' correction), calculated by reviewer.

From: 3, Assessment of clinical effectiveness

Cover of The Effectiveness and Cost-Effectiveness of Donepezil, Galantamine, Rivastigmine and Memantine for the Treatment of Alzheimer's Disease (Review of Technology Appraisal No. 111): A Systematic Review and Economic Model
The Effectiveness and Cost-Effectiveness of Donepezil, Galantamine, Rivastigmine and Memantine for the Treatment of Alzheimer's Disease (Review of Technology Appraisal No. 111): A Systematic Review and Economic Model.
Health Technology Assessment, No. 16.21.
Bond M, Rogers G, Peters J, et al.
Southampton (UK): NIHR Journals Library; 2012 Apr.
© 2012, Crown Copyright.

Included under terms of UK Non-commercial Government License.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.