TABLE 34Markers of internal validity of included studies: head-to-head comparisons

StudyWas the assignment to the treatment groups really random?Was the treatment allocation concealed?Were the groups similar at baseline in terms of prognostic factors?Were the eligibility criteria specified?Were outcome assessors blinded to the treatment allocation?Was the care provider blinded?Was the patient blinded?Were the point estimates and measure of variability presented for the primary outcome measure?Did the analyses include an ITT analysis?Were withdrawals and dropouts completely described?
Bullock et al. (2005)147AdequateAdequateReported – yesInadequatePartialAdequateAdequateAdequateAdequateAdequate
Cumbo (2005)99UnknownUnknownUnknownaUnknownUnknownUnknownbUnknownbAdequateAdequatecAdequated
Ancoli-Israel et al. (2005)149UnknownUnknownReported – yesUnknownPartialPartialPartialAdequatePartialAdequate
Nordberg et al. (2009)147UnknownUnknownReported – yeseUnknownInadequatef,gInadequateInadequatefAdequateInadequateAdequate
a

Mean or range across all trial arms only given.

b

Open-label trial.

c

All patients completed follow-up.

d

No dropouts occurred.

e

Although note fewer women in donepezil group.

f

Open-label trial.

g

Open-label trial, monitoring personnel were not blinded (although laboratory personnel who processed cerebrospinal fluid samples were blinded).

From: 3, Assessment of clinical effectiveness

Cover of The Effectiveness and Cost-Effectiveness of Donepezil, Galantamine, Rivastigmine and Memantine for the Treatment of Alzheimer's Disease (Review of Technology Appraisal No. 111): A Systematic Review and Economic Model
The Effectiveness and Cost-Effectiveness of Donepezil, Galantamine, Rivastigmine and Memantine for the Treatment of Alzheimer's Disease (Review of Technology Appraisal No. 111): A Systematic Review and Economic Model.
Health Technology Assessment, No. 16.21.
Bond M, Rogers G, Peters J, et al.
Southampton (UK): NIHR Journals Library; 2012 Apr.
© 2012, Crown Copyright.

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