Table 2Use of different study types for each component of this comparative effectiveness review

Study CategoryUse in the Comparative Effectiveness Review
Survey of Existing Research (KQ1)Evaluation of Effectiveness (KQ2–4)Evaluation of Harms (KQ2–4)
Systematic ReviewMeta-Analysis
Randomized clinical trialsFive key indicationsXXX*X
Other indicationsXOutside Project Scope
Comparative observational studiesFive key indications and good qualityXXX*X
Five key indications and fair qualityXXInsufficient QualityX
Five key indications and poor qualityXInsufficient Quality for detailed review**X
Other indicationsXOutside Project Scope
Non-comparative observational studiesFive key indications and ≥15 patientsOutside Project ScopeContributes No InformationX
Other indications or < 15 patients reportedOutside Project Scope

X represents use of this study category for each component.

*

For the indications where a sufficient number of quality studies existed to justify the use of meta-analytic tools. We defined a sufficient number to be a total of at least two studies of fair or better quality, including at least one study of good quality.

**

Poor quality comparative observational studies were not reviewed in detail in the evaluation of effectiveness, but their data were included in the outcomes tables so that qualitative sensitivity analyses could be performed by placing their findings in the context of the findings of the higher quality studies.

Because certain study categories fell outside of the project scope, they were not used for the indicated evaluations in the comparative effectiveness review.

From: Methods

Cover of Comparative Effectiveness of In-Hospital Use of Recombinant Factor VIIa for Off-Label Indications vs. Usual Care
Comparative Effectiveness of In-Hospital Use of Recombinant Factor VIIa for Off-Label Indications vs. Usual Care [Internet].
Comparative Effectiveness Reviews, No. 21.
Yank V, Tuohy CV, Logan AC, et al.

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