TABLE 34Characteristics of the included RCT of different antibiotics in the inpatient setting

Study details and target populationInterventionComparator
Dubray et al. 200859

Design: RCT

Location: TFC in Sudan

Length of follow-up: not clearly stated, but appears to be until exit from TFC

No. enrolled: 460

Target population: severely malnourished children with weight ≥ 5 kg and height > 65 cm and ≤ 109.9 cm (usually corresponding to age 6–59 months); displaced population
Ceftriaxone (75 mg/kg/day) administered via i.m. injection once daily for 2 days

Selected baseline characteristics

Mean age ± SD: 17 ± 7 months

Sex F : M, %: 48 : 52

W/H < 70% of median,a n (%): 169 (74.1)

MUAC < 110 mm,b n (%): 36 (15.8)

W/A: NR

Fever (≥ 37.5ºC), n (%): 70 (30.7)

Moderate dehydration, n (%): 33 (14.5)

Paracheck positive,c n (%): 4 (1.9)
Amoxicillin (80 mg/kg/day) administered orally twice daily over 5 days

Selected baseline characteristics

Mean age ± SD: 18 ± 8 months

Sex F : M, %: 45 : 55

W/H < 70% of median,a n (%): 166 (72.1)

MUAC < 110 mm,b n (%): 36 (15.7)

W/A: NR

Fever (≥ 37.5ºC), n (%): 67 (29.1)

Moderate dehydration, n (%): 23 (10.1)

Paracheck positive,c n (%): 2 (0.9)

NR, not reported.

a

No bilateral oedema, W/H compared with the NHCS 1977 growth reference curves.61

b

No bilateral oedema and W/H ≥ 70%.

c

No other specific infection was diagnosed.

From: 4, Assessment of clinical effectiveness

Cover of The Effectiveness of Interventions to Treat Severe Acute Malnutrition in Young Children: A Systematic Review
The Effectiveness of Interventions to Treat Severe Acute Malnutrition in Young Children: A Systematic Review.
Health Technology Assessment, No. 16.19.
Picot J, Hartwell D, Harris P, et al.
Southampton (UK): NIHR Journals Library; 2012 Apr.
© 2012, Crown Copyright.

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