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Overview of the literature

As shown in Figure 1, the electronic searches identified 127,550 citations. After deduplication, both within and between the databases, 102,267 citations had the inclusion criteria applied at stage one. This resulted in 96,077 citations being excluded, 246 of which were reviews.

Results of meta-analyses

In order to explore the general profile of the RCT data, we first carried out an exploratory MA. This analysis included all 40 analyses for which metrics suited to conversion to ORs were available (see Chapter 2, Meta-analysis). The number of ‘risk ratio’ analyses was too small to be meaningfully combined for this purpose.

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