TABLE 10Baseline patient characteristics

Study numberStudyAge: mean (SD), yearsSeverity of illness: measure, mean (SD)
IVIGControlIVIGControl
1Rodriguez et al. (2005)4261.3 (19.9)65.9 (18.2)APACHE II 16.1 (5.9)APACHE II 15.2 (6.1)
2Hentrich et al. (2006)4348.8 (NR)51.0 (NR)NRNR
3Karatzas et al. (2002)4450.5 (3.33)50.7 (7.4)APACHE II 21.3 (7.2)APACHE II 23.5 (7.9)
4Tugrul et al. (2002)4542 (18)49.3 (20.6)APACHE II 10.5 (4.6)APACHE II 14 (8.5)
5Behre et al. (1995)4650 (NR)55 (NR)
6Schedel et al. (1991)4746 (16)37 (18)APACHE II 30aAPACHE II 24a
7Wesoly et al. (1990)4844.7 (19)54.8 (17)Sepsis score 14.8 (2.5)Sepsis score 16.3 (3.6)
8Spannbruker et al. (1987)4950.8 (15.5)54.5 (12)NRNR
9Dominioni et al. (1996)5055 (19)57 (19)Sepsis score 23 (4)Sepsis score 23 (4)
10Burns et al. (1991)5161.5 (NR)59.8 (NR)NRNR
11De Simone et al. (1988)5245 (4)45 (5)NRbNRb
12Werdan et al. (2007)5357.2 (13.7)57.7 (13.6)APACHE II 27.6 (4.5)APACHE II 28 (4.5)
13Grundmann and Hornung (1988)5446.9 (NR)52.8 (NR)NRNR
14Darenberg et al. (2003)5651.3 (NR)52.6 (NR)SAPS II 53 (NR)
SOFA 11 (NR)
SAPS II 51 (NR)
SOFA 11 (NR)
15Lindquist et al. (1981)5748.3 (NR)39.2 (NR)NRNR
16Masaoka et al. (2000)58NRNRNRNR
17Yakut et al. (1998)5532 (16)31 (16)APACHE II 16 (4)APACHE II 16 (5)

NR, not reported.

a

Approximated from figure.

b

Description of sepsis syndromes provided suggests high severity of illness.

From: 3, Clinical effectiveness of intravenous immunoglobulin for severe sepsis and septic shock

Cover of An Evaluation of the Feasibility, Cost and Value of Information of a Multicentre Randomised Controlled Trial of Intravenous Immunoglobulin for Sepsis (Severe Sepsis and Septic Shock): Incorporating a Systematic Review, Meta-Analysis and Value of Information Analysis
An Evaluation of the Feasibility, Cost and Value of Information of a Multicentre Randomised Controlled Trial of Intravenous Immunoglobulin for Sepsis (Severe Sepsis and Septic Shock): Incorporating a Systematic Review, Meta-Analysis and Value of Information Analysis.
Health Technology Assessment, No. 16.7.
Soares MO, Welton NJ, Harrison DA, et al.
Southampton (UK): NIHR Journals Library; 2012 Feb.
© 2012, Crown Copyright.

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