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Soares MO, Welton NJ, Harrison DA, et al. An Evaluation of the Feasibility, Cost and Value of Information of a Multicentre Randomised Controlled Trial of Intravenous Immunoglobulin for Sepsis (Severe Sepsis and Septic Shock): Incorporating a Systematic Review, Meta-Analysis and Value of Information Analysis. Southampton (UK): NIHR Journals Library; 2012 Feb. (Health Technology Assessment, No. 16.7.)

Appendix 7Results of parametric survival models for long-term survival

TABLE 46Goodness of fit of statistical models (AIC) based on alternative distributions and sets of covariates used to model time from hospital discharge to death

DistributionAge model (model i)APACHE II model (model ii)OD model (model iii)
Exponential949.7951.3952.5
Weibull932.8934.4936.2
Log-normal934.9937.3938.4

OD, organ dysfunction.

TABLE 47Estimated coefficients from alternative models used to evaluate time from hospital discharge to death, all based on the Weibull distribution

Coefficient (SE)Age model (model i)APACHE II model (model ii)OD model (model iii)
Intercept10.6 (1.05)a9.91 (0.795)a10.59(1.133)a
Age at admission−0.029 (0.017)a−0.029 (0.017)a
APACHE II score−0.041 (0.032)a
Two or more ODs0.328 (0.674)
Renal OD0.640 (0.906)
CV OD−0.230 (0.724)
CV and renal OD−1.537 (1.093)
Log(scale)0.527 (0.133)a0.526 (0.133)a0.516 (0.132)a

CV, cardiovascular; OD, organ dysfunction.

a

p<0.05.

TABLE 48Estimated hazard ratios from alternative models used to evaluate time from hospital discharge to death, all based on the Weibull distribution

Hazard ratioAge model (model i)APACHE II model (model ii)OD model (model iii)
Age at admission1.05a1.05a
APACHE II score1.07a
Two or more ODs0.58
Renal OD0.34
CV OD1.47
CV and renal OD13.1

CV, cardiovascular; OD, organ dysfunction.

a

p<0.05.

© 2012, Crown Copyright.

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Cover of An Evaluation of the Feasibility, Cost and Value of Information of a Multicentre Randomised Controlled Trial of Intravenous Immunoglobulin for Sepsis (Severe Sepsis and Septic Shock): Incorporating a Systematic Review, Meta-Analysis and Value of Information Analysis
An Evaluation of the Feasibility, Cost and Value of Information of a Multicentre Randomised Controlled Trial of Intravenous Immunoglobulin for Sepsis (Severe Sepsis and Septic Shock): Incorporating a Systematic Review, Meta-Analysis and Value of Information Analysis.
Health Technology Assessment, No. 16.7.
Soares MO, Welton NJ, Harrison DA, et al.
Southampton (UK): NIHR Journals Library; 2012 Feb.

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    Results of parametric survival models for long-term survival - An Evaluation of the Feasibility, Cost and Value of Information of a Multicentre Randomised Controlled Trial of Intravenous Immunoglobulin for Sepsis (Severe Sepsis and Septic Shock): Incorporating a Systematic Review, Meta-Analysis and Value of Information Analysis
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