Table 24Monotherapy versus combined therapy (maintaining SSRI and adding other augmenting agents)

Quality AssessmentSummary of Findings
No. of PatientsEffectQualityImportance
No. of StudiesDesignLimitationsInconsistencyIndirectnessImprecisionOther ConsiderationsCombined TherapyMonotherapyRR or (% A/E)
Outcome Response
680,84,86,89,93,114RCTStudy LimitationsInconsistentIndirectImprecise2352270.23 to 4.55InsufficientCritical
Outcome Remission
287,101,114,132RCTStudy LimitationsConsistentIndirectImprecise2302271.06 to 1.20InsufficientCritical
Outcome of Suicidality
189RCTStudy limitationsN/ADirectN/AN/AN/A% range (10 to 45)InsufficientImportant
Outcome of Weight Gain
0N/AN/AN/ADirectN/AN/AN/AN/AInsufficientImportant
Outcome of Sexual Dysfunction
184RCTStudy limitationsN/ADirectN/AN/AN/A% range (10 to 45)InsufficientImportant

A/E = adverse event; N/A = not applicable; No. = number; RCT = randomized controlled trial; RR = relative risk; SSRI = selective serotonin reuptake inhibitors

From: Results

Cover of Treatment for Depression After Unsatisfactory Response to SSRIs
Treatment for Depression After Unsatisfactory Response to SSRIs [Internet].
Comparative Effectiveness Reviews, No. 62.
Santaguida PL, MacQueen G, Keshavarz H, et al.

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