Table 23Strength of evidence for cardiovascular drugs with and without coenzyme Q10—Intermediate outcomes

Cardiovascular drug(s)/OutcomeRisk of biasConsistencyDirectnessPrecisionGradeTreatment effect and conclusion*
MD (95% CI)
Statins
CRP57-----No difference
0.02 mg/L (−0.64, 0.68)
HDL-C (mg/dL)38,57ModerateConsistentIndirectImpreciseInsufficientInconclusive
5.02 mg/dL (−3.73, 13.77)57
Arm-specific median change 0.39 versus −0.77, p=0.6538
LDL-C (mg/dL)38,57ModerateConsistentIndirectImpreciseInsufficientInconclusive
8.12 mg/dL (−3.79, 20.03) )57
Arm-specific median change −65.73 versus −50.27, p=0.5338
TC (mg/dL) 38,57-----Inconclusive
11.9 (−3.55, 27.53)57
Arm-specific median change −58.00 versus −61.87, p=0.5738
TG (mg/dL)38,57ModerateConsistentIndirectImpreciseInsufficientInconclusive
−21.26 (−48.88, 6.36) 57
Arm-specific median change −35.43 versus −26.57, p=0.9038
ACE inhibitors
Ejection fraction (%)54-----No difference
0 (−4.75, 4.75)
Fenofibrate
HDL-C (mg/dL) 58ModerateNAIndirectPreciseLowNo difference
−1.55 (−6.78, 3.68)
LDL-C (mg/dL) 58ModerateNAIndirectImpreciseInsufficientInconclusive
3.87 (−19.30, 27.04)
TC (mg/dL) 58-----Inconclusive
0 (−23.17, 23.17)
TG (mg/dL) 58ModerateNAIndirectImpreciseInsufficientInconclusive
8.85 (−52.49, 70.19)
Non-HDL-C (mg/dL) 58ModerateNAIndirectImpreciseInsufficientInconclusive
0.87 (−22.30, 24.04)
SBP (mmHg) 58ModerateNAIndirectImpreciseInsufficientInconclusive
−3.40 (−15.56, 8.76)

Notes:

*

Mean difference and 95 percent confidence interval; range for mean difference given only when evidence consists of multiple studies that were not pooled; (−) is indicated where non-gradable outcomes are reported (for example TC, or CRP)

Arm-specific median change (from baseline) was not used to assess the domain of precision

Abbreviations: ACE = angiotensin-converting enzyme; CHD = coronary heart disease; CRP = C-reactive protein; HDL-C = high density lipoprotein-cholesterol; LDL-C = low density lipoprotein-cholesterol; NA = not applicable; NR = not reported; TC = total cholesterol; TG = triglycerides; RCT = randomized controlled trial; SBP = systolic blood pressure; wk(s) = week(s); yr(s) = year(s).

From: Results

Cover of Dietary Supplements in Adults Taking Cardiovascular Drugs
Dietary Supplements in Adults Taking Cardiovascular Drugs [Internet].
Comparative Effectiveness Reviews, No. 51.
Seely D, Kanji S, Yazdi F, et al.

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