Study ID:
Guideline topic:Key question no:
Checklist completed by:
SECTION 1: INTERNAL VALIDITY
In a well-conducted RCT study:In this study this criterion is:
(Circle one option for each question)
1.1The study addresses an appropriate and clearly focused question.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
1.2The assignment of subjects to treatment groups is randomised.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
1.3An adequate concealment method is used.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
1.4Subjects and investigators are kept ‘blind’ about treatment allocation.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
1.5The treatment and control groups are similar at the start of the trial.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
1.6The only difference between groups is the treatment under investigation.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
1.7All relevant outcomes are measured in a standard, valid and reliable way.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
1.8What percentage of the individuals or clusters recruited into each treatment arm of the study dropped out before the study was completed?
1.9All the subjects are analysed in the groups to which they were randomly allocated (often referred to as intention-to-treat analysis).Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
1.10Where the study is carried out at more than one site, results are comparable for all sites.Well coveredNot addressed
Adequately addressedNot reported
Poorly addressedNot applicable
SECTION 2: OVERALL ASSESSMENT OF THE STUDY
2.1How well was the study done to minimise bias? Code + +, + or −

From: Appendix 11, Quality checklists for clinical studies and reviews

Cover of Alcohol-Use Disorders
Alcohol-Use Disorders: Diagnosis, Assessment and Management of Harmful Drinking and Alcohol Dependence.
NICE Clinical Guidelines, No. 115.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2011.
Copyright © 2011, The British Psychological Society & The Royal College of Psychiatrists.

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