Possible approach for summary assessments outcome (across domains) within and across studies

Risk of biasInterpretationWithin a studyAcross studies
Low risk of biasPlausible bias unlikely to seriously alter the results.Low risk of bias for all key domains.Most information is from studies at low risk of bias.
Unclear risk of biasPlausible bias that raises some doubt about the results.Unclear risk of bias for one or more key domains.Most information is from studies at low or unclear risk of bias.
High risk of biasPlausible bias that seriously weakens confidence in the results.High risk of bias for one or more key domains.The proportion of information from studies at high risk of bias is sufficient to affect the interpretation of the results.

From: APPENDIX D, CRITERIA USED IN QUALITY ASSESSMENT OF RANDOMIZED CONTROLLED TRIALS

Cover of Suicide Prevention Interventions and Referral/Follow-Up Services: A Systematic Review
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O'Neil ME, Peterson K, Low A, et al.
Washington (DC): Department of Veterans Affairs (US); 2012 Mar.

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