Table 97Strength of evidence for final, intermediate and adverse outcomes comparing injectable pharmacologic prophylaxis versus mechanical prophylaxis in patients who had elective spine surgery

Quality AssessmentSummary of Findings
OutcomeNumber of studiesDesignRisk of BiasConsistencyDirectnessPrecisionQuality
Symptomatic objectively confirmed VTE0---------------Insufficient
Major venous thromboembolism0---------------Insufficient
Pulmonary Embolism0---------------Insufficient
Fatal pulmonary embolism0---------------Insufficient
Non-fatal pulmonary embolism0---------------Insufficient
Post thrombotic syndrome0---------------Insufficient
Mortality0---------------Insufficient
Mortality due to bleeding0---------------Insufficient
Health related quality of life0---------------Insufficient
Deep vein thrombosis0---------------Insufficient
Asymptomatic deep vein thrombosis0---------------Insufficient
Symptomatic deep vein thrombosis0---------------Insufficient
Proximal deep vein thrombosis0---------------Insufficient
Distal deep vein thrombosis0---------------Insufficient
Major bleeding0---------------Insufficient
Major bleeding leading to reoperation0---------------Insufficient
Minor bleeding0---------------Insufficient
Surgical site bleeding0---------------Insufficient
Bleeding leading to infection0---------------Insufficient
Bleeding leading to transfusion0---------------Insufficient
Heparin-induced thrombocytopenia0---------------Insufficient
Discomfort0---------------Insufficient
Readmission0---------------Insufficient
Reoperation0---------------Insufficient

From: Appendix H, Strength of Evidence Rating

Cover of Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Venous Thromboembolism Prophylaxis in Orthopedic Surgery [Internet].
Comparative Effectiveness Reviews, No. 49.
Sobieraj DM, Coleman CI, Tongbram V, et al.

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