Table 96Strength of evidence for final, intermediate and adverse outcomes comparing injectable pharmacologic prophylaxis versus mechanical prophylaxis in patients who had surgical repair of a lower extremity injury distal to the hip

Quality AssessmentSummary of Findings
OutcomeNumber of studiesDesignRisk of BiasConsistencyDirectnessPrecisionQuality
Symptomatic objectively confirmed VTE0---------------Insufficient
Major venous thromboembolism0---------------Insufficient
Pulmonary Embolism0---------------Insufficient
Fatal pulmonary embolism0---------------Insufficient
Non-fatal pulmonary embolism0---------------Insufficient
Post thrombotic syndrome0---------------Insufficient
Mortality0---------------Insufficient
Mortality due to bleeding0---------------Insufficient
Health related quality of life0---------------Insufficient
Deep vein thrombosis0---------------Insufficient
Asymptomatic deep vein thrombosis0---------------Insufficient
Symptomatic deep vein thrombosis0---------------Insufficient
Proximal deep vein thrombosis0---------------Insufficient
Distal deep vein thrombosis0---------------Insufficient
Major bleeding0---------------Insufficient
Major bleeding leading to reoperation0---------------Insufficient
Minor bleeding0---------------Insufficient
Surgical site bleeding0---------------Insufficient
Bleeding leading to infection0---------------Insufficient
Bleeding leading to transfusion0---------------Insufficient
Heparin-induced thrombocytopenia0---------------Insufficient
Discomfort0---------------Insufficient
Readmission0---------------Insufficient
Reoperation0---------------Insufficient

From: Appendix H, Strength of Evidence Rating

Cover of Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Venous Thromboembolism Prophylaxis in Orthopedic Surgery [Internet].
Comparative Effectiveness Reviews, No. 49.
Sobieraj DM, Coleman CI, Tongbram V, et al.

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