This figure depicts the analysis of the impact of injectable low molecular weight heparin prophylaxis versus injectable or oral direct thrombin inhibitor prophylaxis on pulmonary embolism in patients who had major orthopedic surgery limited to trials published from 2001- present. Two trials are included in this analysis with each trial including two separate comparisons. The first trial by Eriksson and colleagues in 2007 included two separate comparisons. The first comparison provided a relative risk of 3.04 with a 95 percent confidence interval of 0.37 to 25.12. The second comparison provided a relative risk of 0.60 with a 95 percent confidence interval of 0.12 to 3.06. The second trial by Eriksson and colleagues also in 2007 included two separate comparisons. The first comparison provided a relative risk of 1.02 with a 95 percent confidence interval of 0.08 to 13.64. The second comparison provided a relative risk of 3.94 with a 95 percent confidence interval of 0.29 to 52.91. The combined effect of these two trials showed a relative risk of 1.25 with a 95 percent confidence interval of 0.35 to 4.39. The I-squared value was 0 percent.

Figure 71Impact of injectable low molecular weight heparin versus oral or injectable direct thrombin inhibitors on pulmonary embolism in patients undergoing major orthopedic surgery limited to trials published from 2001 to the present

I2: 0 percent

Legend: The squares represent individual point estimates. The size of the square represents the weight given to each study in the meta-analysis. Horizontal lines through each square represent 95 percent confidence intervals. The diamond represents the combined results. The solid vertical line extending from 1 is the null value.

From: Appendix G, Forest Plots

Cover of Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Venous Thromboembolism Prophylaxis in Orthopedic Surgery [Internet].
Comparative Effectiveness Reviews, No. 49.
Sobieraj DM, Coleman CI, Tongbram V, et al.

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