This figure depicts the meta-analysis of the impact of pharmacologic prophylaxis versus no prophylaxis on deep vein thrombosis in patients who had major orthopedic surgery limited to total knee replacement surgery. Four trials were included in the analysis with both trials by Fuji and colleagues each contributing to two separate comparisons, reported individually here. The first trial by Fuji and colleagues in 2010 included two separate comparisons. The first comparison provided a relative risk of 0.58 with a 95 percent confidence interval of 0.40 to 0.84. The second comparison provided a relative risk of 0.42 with a 95 percent confidence interval of 0.28 to 0.65. The second trial by Chin and colleagues in 2009 provided a relative risk of 0.25 with a 95 percent confidence interval of 0.11 to 0.57. The third trial by Fuji and colleagues in 2008 provided two separate comparisons. The first comparison provided a relative risk of 0.56 with a 95 percent confidence interval or 0.37 to 0.84. The second comparison provided a relative risk of 0.49 with a 95 percent confidence interval of 0.32 to 0.75. The fourth trial by McKenna and colleagues in 1980 provided a relative risk of 1.04 with a 95 percent confidence interval of 0.57 to 1.77. The combined effect of the four trials showed a relative risk of 0.54 with a 95 percent confidence interval of 0.40 to 0.73. The I- squared value was 61.4 percent.

Figure 24Impact of pharmacologic prophylaxis versus no prophylaxis on deep vein thrombosis in patients who had major orthopedic surgery limited to total knee replacement surgery

I2: 61.4 percent

Legend: The squares represent individual point estimates. The size of the square represents the weight given to each study in the meta-analysis. Horizontal lines through each square represent 95 percent confidence intervals. The diamond represents the combined results. The solid vertical line extending from 1 is the null value.

From: Appendix G, Forest Plots

Cover of Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Venous Thromboembolism Prophylaxis in Orthopedic Surgery [Internet].
Comparative Effectiveness Reviews, No. 49.
Sobieraj DM, Coleman CI, Tongbram V, et al.

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