This figure depicts the meta-analysis of the impact of injectable low molecular weight heparins versus no prophylaxis on mortality in patients who had major orthopedic surgery. Eight trials were included in the analysis. The first trial by Yokote and colleagues in 2011 was excluded because no events occurred in either group. The second trial by Chin and colleagues in 2009 was excluded from the analysis because no events occurred in either arm. The third trial by Samama and colleagues in 1997 was excluded from the analysis because no events occurred in either arm. The fourth trial by Jorgensen and colleagues in 1992 provided an odds ratio of 0.95 with a 95 percent confidence interval of 0.20 to 4.52. The fifth trial by Lassen and colleagues in 1991 provided an odds ratio of 1.04 with a 95 percent confidence interval of 0.07 to 16.81. The sixth trial by Torholm and colleagues in 1991 provided an odds ratio of 6.90 with a 95 percent confidence interval of 0.14 to 348.44. The seventh trial by Sorensen and colleagues in 1990 provided an odds ratio of 1.07 with a 95 percent confidence interval 0.07 to 17.44. The eighth trial by Turpie and colleagues in 1986 provided an odds ratio of 0.14 with a 95 percent confidence interval of 0.003 to 6.82. The combined effect of the five trials showed an odds ratio of 0.98 with a 95 percent confidence interval of 0.32 to 3.01, an I-squared value of zero percent and an Egger's p-value of 0.962.

Figure 19Impact of injectable low molecular weight heparins versus no prophylaxis on mortality in patients who had major orthopedic surgery

I2: 0 percent

Egger's p-value: 0.962

Legend: The squares represent individual point estimates. The size of the square represents the weight given to each study in the meta-analysis. Horizontal lines through each square represent 95 percent confidence intervals. The diamond represents the combined results. The solid vertical line extending from 1 is the null value.

From: Appendix G, Forest Plots

Cover of Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Venous Thromboembolism Prophylaxis in Orthopedic Surgery [Internet].
Comparative Effectiveness Reviews, No. 49.
Sobieraj DM, Coleman CI, Tongbram V, et al.

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