This figure depicts the meta-analysis of the impact of injectable low molecular weight heparin prophylaxis versus injectable or oral factor Xa antagonist prophylaxis on major bleeding leading to reoperation in patients undergoing major orthopedic surgery limited to total hip replacement. Two trials were included in the analysis, with comparisons presented individually here. The first trial by Lassen and colleagues in 2002 provided an odds ratio of 0.61 with a 95 percent confidence interval of 0.15 to 2.44. The second trial by Turpie and colleagues in 2002 provided an odds ratio of 1.00 with a 95 percent confidence interval of 0.14 to 7.10. The combined effect of the two trials showed an odds ratio of 0.72 with a 95 percent confidence interval of 0.23 to 2.23. The I-squared value was 0 percent

Figure 173Impact of injectable low molecular weight heparin versus injectable or oral factor Xa antagonists on major bleeding leading to reoperation in patients undergoing major orthopedic surgery limited to total hip replacement

I2: 0 percent

Legend: The squares represent individual point estimates. The size of the square represents the weight given to each study in the meta-analysis. Horizontal lines through each square represent 95 percent confidence intervals. The diamond represents the combined results. The solid vertical line extending from 1 is the null value.

From: Appendix G, Forest Plots

Cover of Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Venous Thromboembolism Prophylaxis in Orthopedic Surgery [Internet].
Comparative Effectiveness Reviews, No. 49.
Sobieraj DM, Coleman CI, Tongbram V, et al.

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