This figure depicts the meta-analysis of the impact of injectable low molecular weight heparin prophylaxis versus oral vitamin k antagonist prophylaxis on major bleeding in patients undergoing major orthopedic surgery limited to total knee replacement. Four trials were included in the analysis. The first trial by Lassen and colleagues in 2007 was excluded because there were no events in the groups compared. The second trial by Fitzgerald and colleagues in 2001 provided an odds ratio of 2.26 with a 95 percent confidence interval of 0.75 to 6.83. The third trial by Leclerc and colleagues in 1996 provided an odds ratio of 1.16 with a 95 percent confidence interval of 0.39 to 3.48. The fourth trial by Hull and colleagues in 1993 provided an odds ratio of 2.83 with a 95 percent confidence interval of 0.90 to 8.86. The combined effect of the three trials showed an odds ratio of 1.93 with a 95 percent confidence interval of 1.01 to 3.67. The I-squared value was 0 percent

Figure 171Impact of injectable low molecular weight heparin versus oral vitamin K antagonists on major bleeding in patients undergoing major orthopedic surgery limited to total knee replacement surgery

I2: 0 percent

Legend: The squares represent individual point estimates. The size of the square represents the weight given to each study in the meta-analysis. Horizontal lines through each square represent 95 percent confidence intervals. The diamond represents the combined results. The solid vertical line extending from 1 is the null value.

From: Appendix G, Forest Plots

Cover of Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Venous Thromboembolism Prophylaxis in Orthopedic Surgery [Internet].
Comparative Effectiveness Reviews, No. 49.
Sobieraj DM, Coleman CI, Tongbram V, et al.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.