This figure depicts the meta-analysis of the impact of injectable low molecular weight heparin prophylaxis versus mechanical prophylaxis on proximaldeep vein thrombosis in patients who had major orthopedic surgery. Three trials were included in the analysis. The first trial by Warwick and colleagues in 2002 provided a relative risk of 0.12 with a 95 percent confidence interval of 0.00 to 1.05. The second trial by Warwick and colleagues in 1998 provided a relative risk of 0.70 with a 95 percent confidence interval of 0.35 to 1.38. The third trial by Stone and colleagues in 1996 provided a relative risk of 1.00 with a 95 percent confidence interval of 0.11 to 9.28. The combined effect of three trials showed a relative risk of 0.65 with a 95 percent confidence interval of 0.34 to 1.26. The I-squared value was 0 percent. The Egger's p-value could not be calculated because only three studies were available.

Figure 148Impact of injectable low molecular weight heparin prophylaxis versus mechanical prophylaxis on proximal deep vein thrombosis in patients undergoing major orthopedic surgery

I2: 0 percent

Egger's p-value: Too few strata

Legend: The squares represent individual point estimates. The size of the square represents the weight given to each study in the meta-analysis. Horizontal lines through each square represent 95 percent confidence intervals. The diamond represents the combined results. The solid vertical line extending from 1 is the null value.

From: Appendix G, Forest Plots

Cover of Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Venous Thromboembolism Prophylaxis in Orthopedic Surgery [Internet].
Comparative Effectiveness Reviews, No. 49.
Sobieraj DM, Coleman CI, Tongbram V, et al.

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