GRADE evidence profiles 65Other adjunctive treatments: Arginine-glycine-aspartic acid (RGD) peptide matrix

Quality assessmentSummary of findings
No of patientsEffectQuality
No of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsDalteparin (injection)controlRelative
(95% CI)
Absolute
Complete wound healing (6 months) (follow-up 6 months)
1
[S]
RCTserious1no seriousno seriousserious2none14/40 (35.0%)2/25 (8.0%)RR 4.36 (1.08 to 17.65)
NNTB = 4 (2 to 16)
27 more per 100 (from 1 fewer to 100 more)LOW

[S] = Steed el al. (1995). RGD peptide matrix + standard care vs saline gauze + standard care only (control). Standard care = debridement, dressing.

1

Allocation concealment unclear.

2

Total no. of event <300.

From: Appendix E, Full GRADE evidence profiles

Cover of Diabetic Foot Problems
Diabetic Foot Problems: Inpatient Management of Diabetic Foot Problems.
NICE Clinical Guidelines, No. 119.
Centre for Clinical Practice at NICE (UK).
Copyright © 2011, National Institute for Health and Clinical Excellence.

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