GRADE evidence profiles 31Aquacel vs Saline moistened gauze (SMG)

Quality assessmentSummary of findings
No of patientsEffectQuality
No of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsAquacelSMGRelative
(95% CI)
Absolute
Achieved granulation tissue (8 weeks)
1
[P]
RCTserious1no seriousno seriousserious2none4/10 (40%)1/10 (10%)RR 4.00 (0.54 to 29.81)30 more per 100 (from 5 fewer to 100 more)LOW
Mean healing time (days)
1
[P]
RCTserious1no seriousno seriousSerious3none1010Mean healing time (days) (SD):
Aquacel = 127 (46); SMG = 234 (61), p < 0.001
LOW
Complication (infection) (8 weeks)
1
[P]
RCTserious1no seriousno seriousserious2none1/10 (10%)3/10 (30%)RR 0.33 (0.04 to 2.69)20 fewer per 100 (from 29 fewer to 51 more)LOW
1

No allocation concealment.

2

Total no. of events < 300.

3

Total no. of events < 400.

Aquacel = sodium carboxyl-methyl-cellulose dressing

From: Appendix E, Full GRADE evidence profiles

Cover of Diabetic Foot Problems
Diabetic Foot Problems: Inpatient Management of Diabetic Foot Problems.
NICE Clinical Guidelines, No. 119.
Centre for Clinical Practice at NICE (UK).
Copyright © 2011, National Institute for Health and Clinical Excellence.

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