GRADE evidence profile 16wound sizes (and ERS)

Study characteristicsQuality AssessmentSummary of findings
No. of studiesDesignNo. of patientsLimitationInconsistencyIndirectnessImprecisionOther considerationPre-test probabilitySensitivity
(%)
Specificity
(%)
Post-test probability
(+ve)
Post-test probability
(despite [-ve])
Youden indexQuality
Wound size ≥ 2 cm2
2
[E, N]
Cross-sectional40 & 46S
(a)
NNS
(b)
NRange:
0.52 to 0.66
Range:
56 to 88
Range:
77 to 93
Range:
0.81 to 0.94
Range:
0.15 to 0.48
Range:
0.49 to 0.65
Low
Wound size ≥ 3 cm2
1
[E]
Cross-sectional46S
(a)
NNS
(b)
N0.5279770.790.230.56Low
Wound size ≥ 4 cm2
1
[E]
Cross-sectional46S
(a)
NNS
(b)
N0.5267910.890.290.58Low
Wound size ≥ 5 cm2
1
[E]
Cross-sectional46S
(a)
NNS
(b)
N0.5250950.920.360.45Low
ESR rate ≥ 65 mm/h + wound size ≥ 2 cm2
1
[E]
Cross-sectional46S
(a)
NNS
(b)
N0.5283770.800.190.60Low
ESR rate ≥70 mm/h + wound size ≥ 2 cm2
1
[E]
Cross-sectional46S
(a)
NNS
(b)
N0.5279820.830.220.61Low

[E] = Ertugrul (2009): reference standard = Histopathology/bone tissue culture/MRI conventional spin echo

S = serious; N = no serious

(a) = no blinding

(b) = wide ranges of confidence intervals (see forest plot).

From: Appendix E, Full GRADE evidence profiles

Cover of Diabetic Foot Problems
Diabetic Foot Problems: Inpatient Management of Diabetic Foot Problems.
NICE Clinical Guidelines, No. 119.
Centre for Clinical Practice at NICE (UK).
Copyright © 2011, National Institute for Health and Clinical Excellence.

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