Summary of GRADE profile 44Lincosamide antibiotics vs. cephalosporins: Clindamycin (oral) vs. cephalexin (oral) (Lipsky et al. 1990)

No of studiesDesignClindamycin (oral)Cephalexin (oral)Relative risk/NNTB
(95% CI)
AbsoluteGRADE quality
Clinical outcome: cured or improvementa (follow-up varied)
1RCT10/25 (40%)9/27 (33.3%)RR 1.20 (0.59 to 2.46)
NNTB = N/A
7 more per 100 (from 14 fewer to 49 more)Low

Dosage: Clindamycin (300 mg orally), 4 times daily for 2 weeks. Cephalexin (500 mg orally), 4 times daily for 2 weeks.

a

Cured or improvement = resolution of all signs and symptoms or sufficient improvement such that additional antimicrobial therapy was not required.

CI = confidence interval; NNTB = number needed to treat to benefit; RCT = randomised clinical trial; RR = relative risk.

From: 3, Evidence review and recommendations

Cover of Diabetic Foot Problems
Diabetic Foot Problems: Inpatient Management of Diabetic Foot Problems.
NICE Clinical Guidelines, No. 119.
Centre for Clinical Practice at NICE (UK).
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