Table 3Description of studies evaluating an ANA test for JIA in children with undiagnosed MSK pain

Author Year
Location
DesignFundingSource of Study PopulationControlClassification CriteriaAssay MethodPositive Threshold
Fawcett26 1999
U.S.
Case-controlGovernmentNRNRG: Undergoing elective orthopedic surgical proceduresACRIIFPositive if a clearly discernible fluorescence pattern appears at 1:40 serum dilation
Haynes28 1986
U.S.
Case-controlGovernment and non-commercial institutionNRNRG: Age-matched children with nonrheumatic diseasesACRIIFReading of ≥1+ in fluorescence at 1:20 dilution
Jones29 2006
North America
Case-controlNRRandomly selected patients from multiple medical centersNRG: Patients with acute lymphoblastic leukemiaNRNRTiter > 1:80
Lipinska30 2008
Poland
Case-controlAcademic institutionNRNRG: Children with functional CV system dysfunctionILARIIFTiter > 1:320
Nordal31 2009
Norway
Case-controlNon-commercial institutionNRNRG: Children undergoing elective outpatient procedures; no diagnosis of inflammatory diseasesILARIIFTiter > 1:80
Osborn32 1984
U.S.
Case-controlGovernmentPediatric clinicHealthy and ORGACRIIFTiter > 1:40
Siamopoulou-Mavridou33 1991
Greece
Case-controlNRNRHealthyEULARIIFTiter > 1:40
Wakhlu34 2003
India
Case-controlAcademic institutionImmunology clinicHealthyACRIIFTiter: > 1:40

ANA = antinuclear antibody test; ACR = American College of Rheumatology; CV = cardiovascular; EULAR = The European League Against Rheumatism; IIF = indirect immunofluorescence method; ILAR = International League of Associations for Rheumatology; JIA = juvenile idiopathic arthritis; MSK = musculoskeletal; NR = not reported; NRG = nonrheumatic disease group; ORG = other rheumatic diseases group

From: Results: Part Two

Cover of Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Tests for Evaluating Musculoskeletal Complaints in Children
Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Tests for Evaluating Musculoskeletal Complaints in Children [Internet].
Comparative Effectiveness Reviews, No. 50.
Wong KO, Bond K, Homik J, et al.

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