GRADE profile 7Effectiveness of peritoneal dialysis (CAPD and APD) compared with haemodialysis – health-related quality of life (adults)

Quality assessmentSummary of findingsQuality
No of studiesStudy designLimitationsInconsistencyIndirectnessImprecisionPeritoneal dialysis (CAPD and APD)HD (in- centre)Effect (95% CI)
Peritoneal dialysis [CAPD and APD] vs HD (adults)
Health related quality of life: mean (sd) quality-adjusted life year (QALY) score in the first 2 years after the start of dialysis (0 to 100; with higher score better)
1
Korevaar 2003
RCTSome serious limitationsaNot assessablebNo serious indirectnessSome serious imprecisionc54.0 (18.9)59.1 (11.7)Mean QALY score difference between PD and HD −3.1 (−16.1 to 9.9) after adjustment for age, comorbidity, and PKD Unadjusted −5.1 (−14.99 to 4.79)VERY LOW
a

External validity: The total required sample size was calculated to be 100 patients. After an inclusion period of more than 3 years, only 38 patients had been randomised. The trial was stopped early because of disappointing inclusion rates (downgraded one level).

b

Inconsistency was not assessable (downgraded one level) because it was reported in one study.

c

Imprecise based on 10% threshold (downgraded one level).

From: 3, How this guideline was developed

Cover of Peritoneal Dialysis
Peritoneal Dialysis: Peritoneal Dialysis in the Treatment of Stage 5 Chronic Kidney Disease.
NICE Clinical Guidelines, No. 125.
Centre for Clinical Practice at NICE (UK).
Copyright © 2011, National Institute for Health and Clinical Excellence.

All rights reserved. This material may be freely reproduced for educational and not-for-profit purposes. No reproduction by or for commercial organisations, or for commercial purposes, is allowed without the express written permission of NICE.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.