GRADE profile 7Effectiveness of peritoneal dialysis (CAPD and APD) compared with haemodialysis – health-related quality of life (adults)

Quality assessmentSummary of findingsQuality
No of studiesStudy designLimitationsInconsistencyIndirectnessImprecisionPeritoneal dialysis (CAPD and APD)HD (in- centre)Effect (95% CI)
Peritoneal dialysis [CAPD and APD] vs HD (adults)
Health related quality of life: mean (sd) quality-adjusted life year (QALY) score in the first 2 years after the start of dialysis (0 to 100; with higher score better)
Korevaar 2003
RCTSome serious limitationsaNot assessablebNo serious indirectnessSome serious imprecisionc54.0 (18.9)59.1 (11.7)Mean QALY score difference between PD and HD −3.1 (−16.1 to 9.9) after adjustment for age, comorbidity, and PKD Unadjusted −5.1 (−14.99 to 4.79)VERY LOW

External validity: The total required sample size was calculated to be 100 patients. After an inclusion period of more than 3 years, only 38 patients had been randomised. The trial was stopped early because of disappointing inclusion rates (downgraded one level).


Inconsistency was not assessable (downgraded one level) because it was reported in one study.


Imprecise based on 10% threshold (downgraded one level).

From: 3, How this guideline was developed

Cover of Peritoneal Dialysis
Peritoneal Dialysis: Peritoneal Dialysis in the Treatment of Stage 5 Chronic Kidney Disease.
NICE Clinical Guidelines, No. 125.
Centre for Clinical Practice at NICE (UK).
Copyright © 2011, National Institute for Health and Clinical Excellence.

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