GRADE profile 13Effectiveness of peritoneal dialysis – mortality – PD (adults and children)

Quality assessmentSummary of findingsQuality
No of studiesStudy designLimitationsInconsistencyIndirectnessImprecision
PD (adults and children)
Badve 2006
Report from national registryNo serious limitationsNot assessableaSome serious indirectnessbSome serious imprecisioncAdjusted weighted HR for death in PD after transplant vs PD after failure of native kidneys 1.09 (95% CI 0.81 to 1.45), after adjustment for gender, age, race, comorbidities, BMI, smoking, time from commencement of RRT to PD, country of residence; 1.32 (95% CI 0.76 to 2.31), with addition of peritoneal transport statusVERY LOW

Inconsistency was not assessable (downgraded one level) because it was reported in one study.


The study was not a comparative evaluation (downgraded one level).


Imprecise based on 10% threshold (downgraded one level).

From: 3, How this guideline was developed

Cover of Peritoneal Dialysis
Peritoneal Dialysis: Peritoneal Dialysis in the Treatment of Stage 5 Chronic Kidney Disease.
NICE Clinical Guidelines, No. 125.
Centre for Clinical Practice at NICE (UK).
Copyright © 2011, National Institute for Health and Clinical Excellence.

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