Economic profilePanic online versus information control

Study & countryLimitationsApplicabilityOther commentsIncremental cost (£)1Incremental effectICER (£/effect)1Uncertainty1
Klein et al., 2006
Potentially serious limitations2Partially applicable3
  • Time horizon: 6 weeks
  • Cost-consequence analysis
£141See GRADE clinical profile aboveNon-ApplicableNo statistical analysis of costs
Guideline analysis (model 1)
Minor limitations4Directly applicable5
  • Time horizon: 1 year
£354.960.046£7,599/QALYProbability of cost effectiveness at £20,000/QALY: 92%

Costs converted and uplifted to 2009 UK pounds, using PPP exchange rates (http://www​ and the UK HCHS inflation index; assuming study cost year 2004.


Short time horizon; intervention costs only considered; various panic, anxiety and cognition outcomes measured (cost-consequence analysis)


Australian study; narrow perspective (intervention costs only considered); local prices used; no QALYs estimated but outcome measures considered relevant in guideline systematic review of clinical evidence


Limited evidence base (2 RCTs); intervention currently not available in the UK


Analysis conducted to assist guideline development; NHS & personal social services perspective; QALYs estimated based on EQ-5D

From: Appendix 18, GRADE evidence profiles

Cover of Generalised Anxiety Disorder in Adults
Generalised Anxiety Disorder in Adults: Management in Primary, Secondary and Community Care.
NICE Clinical Guidelines, No. 113.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2011.
Copyright © 2011, The British Psychological Society & The Royal College of Psychiatrists.

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