1.23Pregabalin vs Lorazepam for GAD

Quality assessmentSummary of findingsImportance
No of patientsEffectQuality
No of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsPregabalinLorazepamRelative (95% CI)Absolute
HAM-A (Better indicated by lower values)
1randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious1none6668-MD 1.55 lower (3.22 lower to 0.12 higher)⊕⊕⊕○
MODERATE
Non-response
3randomised trialsno serious limitationsserious2no serious indirectnessserious3none232/410 (56.6%)108/200 (54%)RR 1.04 (0.76 to 1.44)22 more per 1000 (from 130 fewer to 238 more)⊕⊕○○
LOW
Non-remission
3randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessno serious imprecisionnone325/410 (79.3%)151/200 (75.5%)RR 1.05 (0.95 to 1.15)38 more per 1000 (from 38 fewer to 113 more)⊕⊕⊕⊕
HIGH
Discontinuation due to adverse events
3randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessno serious imprecisionnone59/410 (14.4%)69/200 (34.5%)RR 0.42 (0.31 to 0.56)200 fewer per 1000 (from 152 fewer to 238 fewer)⊕⊕⊕⊕
HIGH
Dizziness
2randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious4none62/205 (30.2%)22/136 (16.2%)RR 1.85 (1.18 to 2.91)138 more per 1000 (from 29 more to 309 more)⊕⊕⊕○
MODERATE
Somnolence
2randomised trialsno serious limitationsserious2no serious indirectnessserious1none68/205 (33.2%)78/136 (57.4%)RR 0.62 (0.35 to 1.11)218 fewer per 1000 (from 373 fewer to 63 more)⊕⊕○○
LOW
1

Confidence intervals compatible with benefit for pregabalin or no difference

2

I-squared > 50%

3

Confidence intervals compatible with benefit or no benefit

4

Confidence intervals compatible with benefit for lorazepam or no difference

From: Appendix 18, GRADE evidence profiles

Cover of Generalised Anxiety Disorder in Adults
Generalised Anxiety Disorder in Adults: Management in Primary, Secondary and Community Care.
NICE Clinical Guidelines, No. 113.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2011.
Copyright © 2011, The British Psychological Society & The Royal College of Psychiatrists.

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