Table 17.2Fish advice (dietary fish advice + fish oil capsule) vs. fruit advice for stable angina (Follow-up after 3 to 9 yrs)

Quality assessmentSummary of findings
No of patientsEffectQuality
No of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsFish advice (dietary fish advice + fish oil capsule)Fruit advice (Follow-up 6 months after entering the trial)Relative (95% CI)Absolute
All death (Follow-up after 3 to 9 years)
Burr 2003215randomised trialsserious (a)no serious inconsistencyno serious indirectnessserious imprecision (b)None141/764 (18.5%)133/779 (17.1%)RR 1.08 (0.87 to 1.34)14 more per 1000 (from 22 fewer to 58 more)⊕ ⊕ ○ ○

LOW
Cardiac death (Follow-up after 3 to 9 years)
Burr 2003215randomised trialsserious (a)no serious inconsistencyno serious indirectnessserious imprecision (b)None94/764 (12.3%)72/779 (9.2%)RR 1.33 (1 to 1.78)31 more per 1000 (from 0 more to 72 more)⊕ ⊕ ○ ○

LOW
Sudden death (Follow-up after 3 to 9 years)
Burr 2003215randomised trialsserious (a)no serious inconsistencyno serious indirectnessserious imprecision (b)None42/764 (5.5%)30/779 (3.9%)RR 1.43 (0.9 to 2.26)17 more per 1000 (from 4 fewer to 49 more)⊕ ⊕ ○ ○

LOW
a

Burr 2003[209]: Randomised. Baseline characteristics reported, Loss to follow-up not reported. ITT not reported. Allocation concealment not reported.

b

95% CI around the pooled estimate of effect includes both: 1) no effect and 2) appreciable benefit or appreciable harm.

From: 17, Lifestyle Adjustments

Cover of Stable Angina
Stable Angina: Methods, Evidence & Guidance [Internet].
NICE Clinical Guidelines, No. 126.
National Clinical Guidelines Centre (UK).
Copyright © 2011, National Clinical Guidelines Centre.

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