ClinicalMyocardial perfusion imaging:

Groutars 2002178 (Myocardial SPECT using technitiun-99m tetrofosmin): Evidence from one study shows that myocardial perfusion scanning using technetium 99m tetrofosmin offered incremental prognostic information in prediction of cardiac death or non fatal MI [follow-up 2 years].

Elhendy 2005179 (Myocardial SPECT using technitiun-99m tetrofosmin): Evidence from one study shows that stress technetium- tetrofosmin myocardial perfusion imaging is an independent predictor of all cause mortality in patients with stable angina. [mean follow-up 6±1.7 years].

Stratmann 1992180 (Dipyridamole thallium-201 scintigraphy): Evidence from one study shows that presence of a fixed perfusion defect during dipyridamole stress and a history of CABG are independent predictors of cardiac events. The presence of a fixed perfusion defect and a history of peripheral vascular disease were independent predictors of cardiac death [mean follow-up 18 months].

Wiersma 2009181 (Myocardial SPECT): Evidence from one study shows that the presence of severe myocardial ischaemia and insulin use were independent predictors of cardiac death or non fatal MI [follow-up 2.2±0.6 years].

Stratmann 1994182 (Myocardial SPECT using technetium-99m sestamibi and dipyridamole stress): Evidence from one study shows that reversible and fixed perfusion defects on SPECT, history of congestive heart failure, history of diabetes mellitus, and Q waves on pre-test ECG were independent predictors of cardiac death or MI [mean follow-up 13±5 months].

Stratmann 1994183 (Myocardial SPECT using technetium-99m sestamibi and exercise stress): Evidence from one study shows that exercise perfusion abnormalities and reversible perfusion defects were independent predictors of cardiac death or non-fatal MI) [mean follow-up 13±5 months].

Poornima 2004184 (Myocardial SPECT and treadmill ergometry): Evidence from one prognostic study shows that the clinical score (CS) and global stress score (GSS) were significant independent predictors of cardiac death, cardiac death or MI; and cardiac death, MI or revascularisation The independent predictive power of CS appeared to be greater than that of GSS [follow-up 7±1 year].

Vanzetto 1999185 (Myocardial SPECT using thallium 201 and exercise treadmill test): Evidence from one prognostic cohort study shows that exercise tolerance test and SPECT were independent predictors of overall mortality. Exercise tolerance test and SPECT were independent predictors of cardiac death and SPECT was an independent predictor of MI [Follow-up 72±18 months]

Lima 2004186 (Myocardial SPECT using technetium-99m and exercise treadmill test): Evidence from one study shows that SPECT was an independent predictor of cardiac death or MI, and of total cardiac events (cardiac death, MI or myocardial revascularisation). [mean follow-up 34±15 months]
EconomicNo economic evidence was found on this question. A simple cost analysis showed that MPS with SPECT has a cost of £293 per test.

From: 15, Functional and anatomical investigations

Cover of Stable Angina
Stable Angina: Methods, Evidence & Guidance [Internet].
NICE Clinical Guidelines, No. 126.
National Clinical Guidelines Centre (UK).
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