Table 15.5Sekhri 2008175, Multivariate analysis for coronary heart disease death + MI

CovariateCoefficientAdjusted hazard ratio (95% CI)P value
Clinical assessment with significant variables (whole cohort)
Age (10 year increase)0.261.30 (1.21 to 1.39)<0.001
Sex (female v male)−0.280.75 (0.64 to 0.89)0.0008
Typical v atypical1.133.09 (2.58 to 3.71)<0.001
Non-cardiac v atypical chest pain−0.380.68 (0.50 to 0.93)
Diabetes0.451.58 (1.28 to 1.94)<0.001
Clinical assessment plus resting ECG (whole cohort)
Age (10 year increase)0.231.26 (1.17 to 1.35)<0.001
Sex (female v male)−0.270.76 (0.65 to 0.90)0.0013
Typical v atypical chest pain1.042.82 (2.34 to 3.40<0.001
Non-cardiac v atypical chest pain−0.370.69 (0.50 to 0.95)
Diabetes0.411.50 (1.22 to 1.86)0.0002
Q waves0.571.77 (1.24 to 2.53)0.0037
Bundle branch block0.301.36 (0.95 to 1.94)0.1089
Change in ST segment or T wave0.451.57 (1.28 to 1.94)<0.001
Clinical assessment plus resting ECG plus summary exercise ECG
Age (10 year increase)0.101.11 (1.00 to 1.22)0.048
Sex (female v male)−0.050.95 (0.76 to 1.18)0.64
Typical v atypical chest pain0.752.12 (1.66 to 2.71)<0.001
Non-cardiac v atypical chest pain−0.540.58 (0.29 to 1.19)
Diabetes0.361.44 (1.09 to 1.89)0.0134
Q waves0.752.12 (1.28 to 3.49)0.051
Bundle branch block−0.110.90 (0.40 to 2.02)0.79
Change in ST segment or T wave0.291.34 (1.01 to 1.79)0.0078
Positive v negative exercise ECG0.922.53 (1.95 to 3.30)<0.001
Equivocal v negative exercise ECG0.441.55 (1.06 to 2.28
Clinical assessment plus resting ECG plus detailed exercise ECG
Age (10 years increase)0.031.03 (0.85 to 1.25)0.76
Sex (female v male)−0.590.55 (0.37 to 0.83)0.0036
Typical v atypical chest pain0.902.45 (1.62 to 3.70)<0.001
Non-cardiac v atypical chest pain−0.520.59 (0.14 to 2.45)
Diabetes0.031.03 (0.63 to 1.70)0.9023
Q waves0.491.64 (0.64 to 4.18)0.3338
Bundle branch block0.421.53 (0.48 to 4.89)0.5022
Change in ST segment or T wave0.321.37 (0.83 to 2.27)0.2264
Exercise time (minutes)−0.150.86 (0.79 to 0.93)0.0005
Diagnostic change in ST segment0.812.26 (1.44 to 3.53)0.0005

From: 15, Functional and anatomical investigations

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Stable Angina: Methods, Evidence & Guidance [Internet].
NICE Clinical Guidelines, No. 126.
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