Table 16.4Exercise plus low fat diet vs. control

Quality assessmentSummary of findings
No of patientsEffectQuality
No of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsExercise + low fat dietControlRelative (95% CI)Absolute
Cardiac mortality (follow-up 12 months)
Schuler 1992200randomised trialsserious (a,b)no serious inconsistencyno serious indirectnessserious imprecision (c)none2/56 (3.6%)0/57 0%RR 5.09 (0.25 to 103.66)40 more per 1000 (from 20 fewer to 90 more)⊕⊕○○

LOW
Mortality (all) (follow-up 12 months)
Schuler 1992200randomised trialsserious (a,b)no serious inconsistencyno serious indirectnessserious imprecision (c)none2/56 (3.6%)1/57 1.8%RR 2.04 (0.19 to 21.82)19 more per 1000 (from 15 fewer to 375 more)⊕⊕○○

LOW
Non-fatal MI (follow-up 12 months)
Schuler 1992200randomised trialsserious (a,b)no serious inconsistencyno serious indirectnessserious imprecision (c)none0/56 (0%)2/573.5%RR 0.2 (0.01 to 4.15)28 fewer per 1000 (from 35 fewer to 110 more)⊕⊕○○

LOW
a

Only compliant and responsive subjects were selected for this study, so results are likely to be better than those which would be found in a general population of patients with angina.

b

Schuler 1992[194]: Method of randomisation reported. No blinding. More patients dropped out of the study before treatment was complete in the exercise group (29% vs. 9% in the control group). No allowance was made for this in analysis of final dataset. Therefore, the health benefits gained in the exercise group will be an overestimate.

c

95% CI around the pooled estimate of effect includes both: 1) no effect and 2) appreciable benefit or appreciable harm.

From: 16, Rehabilitation

Cover of Stable Angina
Stable Angina: Methods, Evidence & Guidance [Internet].
NICE Clinical Guidelines, No. 126.
National Clinical Guidelines Centre (UK).
Copyright © 2011, National Clinical Guidelines Centre.

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