Table 19.10Statins vs. placebo for Cardiac Syndrome X

Quality assessmentSummary of findings
No of patientsEffectQuality
No of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsStatinsPlaceboRelative (95% CI)Absolute
Total exercise time (Sec) (follow-up 3 months; range of scores: -; better indicated by more)
Kayikcioglu 2003235(d)randomised trialserious (a)no serious inconsistencyno serious indirectnessno serious imprecisionnone1919-MD 78 higher (11.17 lower to 167.17 higher)⊕⊕⊕ ○

MODERATE
Time to 1mm ST depression (Sec) (follow-up 3 months; range of scores: -; better indicated by more)
Kayikcioglu 2003235;

Fabian 2004236(c)
randomised trialserious (b)no serious inconsistencyno serious indirectnessno serious imprecisionnone3939-MD 48.36 lower (60.71 to 36.02 lower)⊕⊕⊕ ○

MODERATE
Hospitalisation for worsening of angina (follow-up 3 months)
Kayikcioglu 2003235randomised trialserious (a)no serious inconsistencyno serious indirectnessno serious imprecisionnone1/19 (5.3%)1/19 (5.3%)RR 1 (0.07 to 14.85)0 fewer per 1000 (from 49 fewer to 734 more)⊕⊕⊕ ○

MODERATE
a

Kayikcioglu 2003[229]: Single blind, randomised, baseline comparisons made. Allocation concealment not reported, 0.5% drop out, intention to treat analysis not reported.

b

Fabian 2004[230]: Randomised, baseline comparisons made. Allocation concealment not reported, blinding not reported, drop out rate not reported, intention to treat analysis not reported. Kayikcioglu 2003[229]: Single blind, randomised, baseline comparisons made. Allocation concealment not reported, 0.5% drop out, intention to treat analysis not reported.

c

Drug dosage: Fabian 2004[230] - Simvastatin 20 mg/day

d

Drug dosage: Pravastatin 40 mg/day.

From: 19, Cardiac syndrome X

Cover of Stable Angina
Stable Angina: Methods, Evidence & Guidance [Internet].
NICE Clinical Guidelines, No. 126.
National Clinical Guidelines Centre (UK).
Copyright © 2011, National Clinical Guidelines Centre.

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