Table 12. Chronic Graft-versus-Host Disease (GVHD) Symptoms in the Lung, Muscles, Fascia, Joints, Hematopoietic and Immune Systems, and Other Symptomsa

Organ or SiteDiagnosticbDistinctivecOther Featuresd Common (Seen with Both Acute and Chronic GVHD)
LungBronchiolitis obliterans diagnosed with lung biopsy Bronchiolitis obliterans diagnosed with PFTs and radiologyf BOOP
Muscles, fascia, jointsFasciitisMyositis or polymyositisf Edema
Muscle cramps
Arthralgia or arthritis
Hematopoietic and immuneThrombocytopenia
Eosinophilia
Lymphopenia
Hypo- or hypergammaglobulinemia
Autoantibodies (AIHA and ITP)
OtherPericardial or pleural effusions
Ascites
Peripheral neuropathy
Nephrotic syndrome
Myasthenia gravis
Cardiac conduction abnormality or cardiomyopathy

AIHA = autoimmune hemolytic anemia; BOOP = bronchiolitis obliterans–organizing pneumonia; ITP = idiopathic thrombocytopenic purpura; PFTs = pulmonary function tests.

Refer to Table 8 footers for definitions of a through f.

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