Table 13.5GRADE evidence summary: atypical antipsychotic 1 vs atypical antipsychotic 2

Outcome/Author (year)Meta-analysis detailsSummary statisticsCommentsGRADE detailsGRADE Comments
Complete response
(Lee 2005)
1 trial;
31 patients; from RCT
No results fro this outcome
  • Study quality: serious limitation-incomplete follow up
  • Directness: Direct
  • Inconsistency: n/a
  • Reporting bias: Adequate
Very small study; No results reported
Duration of delirium
(Lee 2005)
1 trial;
31 patients; from RCT
MD=−1 (95%CI −4.09, 1.89)No significant difference between amisulpride and quetiapine groups
  • Study quality: serous limitation–incomplete follow up
  • Directness: Direct
  • Imprecision: CI crosses threshold
  • Inconsistency: consistent
  • Reporting bias: Adequate
Lower CI crosses 4× MID
GRADE evidence rating: Very low
Severity of delirium
(Lee 2005)
1 trial;
31 patients; from RCT
MD=0 (95%CI) −1.48, 1.48No significant difference on the DRS-R-98 (0–39) between amisulpride and quetiapine groups
  • Study quality: serious limitation–incomplete follow up
  • Directness: Direct
  • Imprecision: Number of patients < 400
  • Inconsistency: consistent
  • Reporting bias: Adequate
Very small study; 25% missing data in 1 arm
GRADE evidence rating: Low
Adverse events
(Lee 2005)
1 trial;
31 patients; from RCT
RR=1No significant adverse events reported such as acute dystonia dyskinesea
  • Study quality: serious limitation–incomplete follow up
  • Directness: Direct
  • Imprecision: Number of patients < 400
  • Inconsistency: consistent
  • Reporting bias: Adequate
Very small study; 25% missing data in 1 arm
GRADE evidence rating: Low

From: 13, Treatment of delirium: pharmacological

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Delirium: Diagnosis, Prevention and Management [Internet].
NICE Clinical Guidelines, No. 103.
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