Antidepressants
monotherapy - placebo controlled trials

AuthorReason for exclusion
Ciaramella 2000Not in English.
Enggaard 2001Pain was induced experimentally in healthy volunteers.
Enggaard 2001Pain was induced experimentally in healthy volunteers.
Forsell 2004Atypical facial pain is not neuropathic pain.
Gerson 1977Control group included the use of trancutaneous electrical nerve stimulation (TEN).
Gobel 1997Not in English.
Gomez-Perez 1985Crossover study with no washout ,no analysis of carry over effect, fluphenazine was added to nortriptyline.
Gordon 1994Pre-emptive study on postoperative acute pain (20 minutes post-operation).
Kadiroglu 2008Low quality, inappropriate randomisation method, blinding not clear, no report on withdrawals or dropouts.
Kvinesdal 1984Crossover study with no washout and no analysis of carry over effect.
Lampl 2002Study on prophylaxis, main outcome is ‘time to pain’.
Langohr 1982Low quality open study, no blinding.
Loldrup 1989Conditions included tension headache, abdominal pain, low back pain, unable to extract data.
Lynch 2002Topical amitriptyline not included in the scope.
Lynch 2005Topical amitriptyline not included in the scope.
Max 1987Randomisation not clear, crossover study with no washout, analysis showed carry over effect.
Max 1992Low quality, randomisation method not stated, blinding not clear, 22 patients not randomised.
McCleane 2000Topical doxepin not included in the scope.
Mendel 1986Study sample < 10.
Panerai 1990Only 3 weeks study period, crossover study with no washout, no analysis of carry over effect.
Pilowsky 1982Crossover study with no washout and no analysis of carry over effect.
Raskin 2006Unclear comparator (routine care). No description of what is routine care.
Rueben 2004Only 2 weeks study period.
Sharav 1987Study population included participants with non-neuropathic conditions. Unable to extract data.
Shlay 1998Study design included acupuncture in treatment and control point in control group.
Sindrup 1989Study sample < 10.
Sindrup 1990aOnly 2 weeks study period.
Sindrup 1990bOnly 2 weeks study period, some carry over effect after clomipramine.
Sindrup 1992aOnly 3 weeks study period.
Sindrup 1992bOnly 2 weeks study period.
Wallace 2002Pain was induced experimentally in healthy volunteers.
Wernicke 2006Unclear comparator (routine care). No description of what is routine care.
Wernicke 2007Unclear comparator (routine care). No description of what is routine care.

From: Appendix 9.4, Lists of excluded studies

Cover of Neuropathic Pain
Neuropathic Pain: The Pharmacological Management of Neuropathic Pain in Adults in Non-Specialist Settings.
NICE Clinical Guidelines, No. 96.
Centre for Clinical Practice at NICE (UK).
Copyright © 2010, National Institute for Health and Clinical Excellence.

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