Table 41GRADE profiles – gabapentin + oxycodone vs gabapentin alone

No. of studiesDesignGaba + Oxyco
(T1)
Gaba
(T2)
Relative risk (95% CI)
[ARI]
[NNTH, 95% CI]
LimitationsInconsistencyIndirectnessImprecisionOther considerationsQuality
PRIMARY OUTCOME: No. of withdrawals owing to adverse effects
1
(PDN1)
RCT27/169
(16.0%)
9/169
(5.3%)
3.00 (1.45, 6.19)
ARI = 10.7%
NNTH = 9.4 (5.7, 23.5)
NNNVSaNVery low
PRIMARY OUTCOME: Constipation (adverse effects)
1
(PDN1)
RCT45/168
(26.8%)
10/167
(6.0%)
4.47 (2.33, 8.58)
ARI = 20.8%
NNTH = 4.8 (3.5, 7.5)
NNNVSaNVery low
PRIMARY OUTCOME: Nausea (adverse effects)
1
(PDN1)
RCT43/168
(25.6%)
18/167
(10.9%)
2.37 (1.43, 3.94)
ARI = 14.7%
NNTH = 6.7 (4.3, 15.0)
NNNVSaNVery low
PRIMARY OUTCOME: Vomiting (adverse effects)
1
(PDN1)
RCT16/168
(9.5%)
7/167
(4.2%)
2.27 (0.96, 5.38)
ARI = 5.3%
NNTH = N/A
NNNVSaNVery low
PRIMARY OUTCOME: Fatigue (adverse effects)
1
(PDN1)
RCT31/168
(18.5%)
14/167
(8.4%)
2.20 (1.21, 3.99)
ARI = 10.1%
NNTH = 9.9 (5.7, 35.2)
NNNVSaNVery low
PRIMARY OUTCOME: Dizziness (adverse effects)
1
(PDN1)
RCT25/168
(14.9%)
6/167
(3.6%)
4.14 (1.74, 9.84)
ARI = 11.3%
NNTH = 8.9 (5.6, 18.6)
NNNVSaNVery low
PRIMARY OUTCOME: Somnolence (adverse effects)
1
(PDN1)
RCT37/168
(22.0%)
9/167
(5.4%)
4.09 (2.04, 8.20)
ARI = 16.6%
NNTH = 6.0 (4.1, 10.4)
NNNVSaNVery low
PRIMARY OUTCOME: Any adverse effects: non-specified
1
(PDN1)
RCT147/168
(87.5%)
119/167
(71.3%)
1.23 (1.10, 1.37)
ARI = 16.2%
NNTH = 6.2 (4.0, 13.0)
NNNVSaNVery low

Relative risks were calculated in the direction of T1 compared with T2.

T1 = treatment 1; T2 = treatment 2; N = No serious; S = Serious; VS = Very serious

Gaba = gabapentin; Oxyco = oxycodone; PDN = painful diabetic neuropathy; N/A = not applicable.

a

GDG consensus: if there is only 1 study with total number of adverse effects less than 100, the GDG decided that the quality should be graded as ‘very low’.

1

From: 2, How this guideline was developed

Cover of Neuropathic Pain
Neuropathic Pain: The Pharmacological Management of Neuropathic Pain in Adults in Non-Specialist Settings.
NICE Clinical Guidelines, No. 96.
Centre for Clinical Practice at NICE (UK).
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